Family emigrated to Buenos Aires, Castillo returned to Europe in 1957. After passing through Vigo he moved to Madrid, where he soon comes into contact with the art critic José María Moreno Galván, who admired his work and introduced into the Madrid artistic circles . In 1958 he starts selling his drawings in the gallery Biosca, and the painter Antonio Saura buy several.

The next year he exhibited his works on paper and watercolors at the Altamira Gallery in Madrid. Little by little, you will decanting by the technique of engraving, which will ultimately their main means of expression, but it will alternate with paint.

In 1960 he is selected for the Biennial of São Paulo in Brazil. Thereafter he exhibits his work internationally in galleries and museums in New York, San Francisco, Tokyo, Paris, Lisbon, Turin, Hanover, Dusseldorf and Geneva. Participates in the Venice Biennale in 1964 and 1976, and in 1970 held a solo exhibition at the Nationalgalerie in Berlin, the first major exhibition in a museum, to a specific period of his career.

He won awards such as the International Drawing (1964) and Painting (1975) of Darmstadt, the City of Pontevedra (1994), and the Living Culture of Fine Arts (2006). He currently lives and works in Ibiza. You can see the work of Jorge Castillo at the Museum of Fine Arts in Lausanne, the Juan March Foundation, the National Galleries in Edinburgh and Berlin, the Museum of Modern Art in San Francisco and Vitoria, the Kunsthalle Bremen, the Albertina in Vienna, the National Library of Spain and the Guggenheim in New York, among others ….